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J.Health Sci., 50(1), 92-96, 2004
Effects of Long-Term Ingestion of Cadmium-Polluted Rice or
Low-Dose Cadmium-Supplemented Diet on the Endogenous
Copper and Zinc Balance in Female Rats
Junichi Nakagawa,*, a Shinshi
Oishi,a Jin
Suzuki,b Yoshiteru
Tsuchiya,c Masanori
Ando,d and Yasuo
Fujimotoe
aDepartment of Environmental Health and Toxicology,
bDepartment of Food Safety, Tokyo Metropolitan Institute of Public Health,
3-24-1, Hyakunincho, Shinjuku-ku, Tokyo 169-0073, Japan,
cCooperative Research and Development Center Yokohama National
University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama, Kanagawa 240-8501, Japan,
dDivision of Environmental Chemistry,
National Institute of Health Science, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan, and
eCollege of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan
The concentrations of endogenous copper (Cu) and zinc (Zn) in the liver and kidney of female rats were
measured after ingestion of cadmium (Cd)-polluted (1.06 ppm) rice or cadmium-supplemented (1.1, 5, 20, and
40 ppm) rice for 12, 18, and 22 months. In the liver, the Cd concentration increases in a dose-dependent manner
for the first 18 months. After 18 months, the concentration remained stationary in the low-dose groups,
increased in the 5-ppm group, and decreased in the 20- and 40-ppm groups. The Cu concentration was almost
unchanged through the experiment, and the Zn concentration increased in a dose-dependent manner. In the
kidneys, changes in the Cd concentration resembled that in the liver. The concentrations of Cu increased in a
dose-dependent manner at 12 and 18 months. The Zn concentration increased more in the 5-ppm group but not
dose dependently.
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