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J.Health Sci., 50(1), 75-81, 2004
Bioavailability of Zinc Yeast in Rats: Stimulatory
Effect on Bone Calcification in Vivo
Masayoshi Yamaguchi,* Aki Igarashi, and Satoshi Uchiyama
Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka,
52-1 Yada, Shizuoka 422-8526, Japan
The bioavailability of zinc yeast as a functional food ingredient in rats was investigated. Zinc yeast, zinc
sulfate, or zinc oxide was used. Serum zinc concentrations were significantly increased by a single oral
administration of zinc yeast, zinc sulfate or zinc oxide at a dose of 10 mg Zn/100 g body weight. A significant increase
was observed 1 hr after administration and it was also seen with the lowest dose of Zn 0.5 mg/100 g of zinc yeast
or zinc oxide. A single oral administration of zinc yeast, zinc sulfate, or zinc oxide (10 mg Zn/100 g) caused a
significant increase in liver zinc content. A significant increase in femoral-diaphyseal and -metaphyseal zinc
contents was observed with the administration of zinc yeast or zinc sulfate. When zinc yeast or zinc oxide
(10 mg Zn/100 g) was orally administered once daily for 7 days to rats, a significant increase in zinc levels in the
serum, liver, and femoral-metaphyseal tissues was seen. Femoral-diaphyseal zinc content was significantly
increased with the administration of zinc yeast. A significant increase in calcium content and alkaline phosphatase
activity in the femoral-diaphyseal and -metaphyseal tissues occurred with the administration of zinc yeast or
zinc oxide. The effect of zinc yeast was greater than that of zinc oxide. This study demonstrated that zinc yeast
has high bioavailability in rats, and that its administration induces an anabolic effect on bone calcification
in vivo. Zinc yeast may be useful as a functional food ingredient.
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