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J.Health Sci., 50(1), 42-46, 2004
Hepatoprotective Nature of Seaweed Alcoholic Extract on Acetaminophen Induced Hepatic
Oxidative Stress
Hanumantha Rao Balaji Raghavendran, Arumugam Sathivel, and Thiruvengadam
Devaki*
Department of Biochemistry and molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, India
We have examined the protective effect of Sargassum
polycystum (Phaeophyceae) alcoholic extract against
a single dose of acetaminophen (intraperitoneally, 800 mg/kg body wt in saline solution) induced hepatic
oxidative stress in experimental rats. The levels of serum glutamate oxaloacetate transaminase, pyruvate
transaminase, lactate dehydrogenase, alkaline phosphatase, bilirubin, creatinine and blood urea were determined. The
activities of glutathione, vitamins (C & E) and the levels of lipid peroxides in the liver homogenate were also
determined. The acetaminophen induction resulted a significant elevation in the levels of serum marker
enzymes, bilirubin, and creatinine with decreased blood urea. The activities of hepatic glutathione and vitamins (C
& E) were also significantly depleted with increased lipid peroxides in acetaminophen intoxicated rats. The oral
pre-treatment with alcoholic extract of Sargassum
polycystum (200 mg/kg body wt/day for a period of 15 days)
showed hepatoprotective nature against acetaminophen induced biochemical changes in the serum and liver
tissue. The animals pre-treated with Sargassum
polycystum extract alone, did not show any toxicity in the liver
tissue, which was confirmed by histopathological studies. These results suggest that the
Sargassum polycystum alcoholic extract may probably acted as a natural antioxidant against acetaminophen induced hepatic oxidative
stress.
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