| |
Software Requirements
Microsoft Internet Explorer 5.01 or higher and Netscape Navigator 4.75 or higher are recommended. |
|
J.Health Sci., 49(6), 524-526, 2003
MRP5b/SMRP mRNA is Highly Expressed in Metallothionein- Deficient Mouse Liver
Toshihiro Suzuki,*, a Mika Agui,a Tadayasu Togawa,a Akira Naganuma,b Kazuto Nishio,c and Shinzo Tanabea
aDepartment of Analytical Biochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan, bLaboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan, and cProject Ward, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
To investigate whether multidrug resistance protein 5 (MRP5) functions as a xenobiotic detoxification factor, we measured MRP mRNA expression levels in metallothionein (MT)-I, II knockout mouse, and the results showed that MRP5b/SMRP, a splicing variant of MRP5, was highly expressed in the liver of MT-I, -II null mice.
|
|
