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J.Health Sci., 49(4), 319-323, 2003
Sulfoconjugation of Bisphenol A in a Human Neuroblastoma
Cell Line, NB-1
Yoshio Ishii and Hiro-omi Tamura*
Kyoritsu College of Pharmacy, 1-5-30, Shibakoen, Minatoku, Tokyo 105-8512, Japan
Bisphenol A (BPA) is a common environmental endocrine disruptor and BPA sulfate has been
demonstrated as one of metabolites of BPA. Since it has been observed to have effects on the central nervous system
(CNS), we examined the effects of sulfoconjugation on the toxicity of BPA in a human neuroblastoma cell line,
NB-1. NB-1 cells showed limited but significant sulfotransferase activity toward BPA
in vitro (Km = 74 mu M, Vmax = 7.8 pmol/min/mg). Accumulation of BPA sulfate was observed for 12 hr to 4 days after 10
mu M BPA was added to a culture of NB-1 cells. These results suggest that BPA is partly detoxified by the sulfoconjugation
reaction in human neuronal cells.
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