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J.Health Sci., 49(4), 316-318, 2003
Genetic Evidence of Resistance to Cadmium Toxicity in
Wistar-Imamichi Rats
Hideaki Shimada,a Yasutaka
Takamure,a
and Yorishige Imamura*, b
aFaculty of Education, Kumamoto University, 2-40-1, Kurokami, Kumamoto 860-8555, Japan and
bFaculty of Pharmaceutical Sciences, Kumamoto University, 5-1, Oe-honmachi, Kumamoto 862-0973, Japan
Resistance to the toxicity of cadmium (Cd) was examined in male Wistar-Imamichi (Wistar-IM)
and Fischer 344 (Fischer) rats. The Wistar-IM strain was confirmed to exhibit strong resistance
compared to the Fischer strain. The resistance in first filial (F1) males was intermediate between that in
Wistar-IM and that in Fischer males. The data from reciprocal crosses indicate that the strong resistance
to Cd toxicity in male Wistar-IM rats is autosomal and inherited as an incompletely dominant
phenotype.
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