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J.Health Sci., 49(4), 285-291, 2003
Adsorption and Stability of Suxamethonium and Its Major Hydrolysis Product
Succinylmonocholine Using Liquid Chromatography-Electrospray Ionization
Mass Spectrometry
Hiroe Tsutsumi,* Mayumi Nishikawa, Munehiro Katagi, and Hitoshi Tsuchihashi
Forensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-ku, Osaka 541-0053, Japan
For the purpose of reliable identification of suxamethonium (SUX) use, the stability and adsorption of SUX
and its specific hydrolysis product succinylmonocholine (SMC) were investigated under various storage
conditions using liquid chromatography-electrospray ionization mass spectrometry (LC-ESI MS). Significant and
slight adsorption to glassware was observed for SUX and SMC, respectively, whereas there was no significant
adsorption to plasticware by either SUX or SMC. The silanization methods for glassware have also been found
to affect the adsorption of SUX to glassware. Additionally, alkaline conditions led to significant loss of both
SUX and SMC due to their hydrolysis, but SMC showed greater stability than SUX under the present storage
conditions, suggesting that SMC is a superior marker for SUX use when stored in alkaline conditions. On the
other hand, there was no significant loss of SUX and SMC under acidic conditions even in human urine at room
temperature or higher (20-38°C), or in distilled water.
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