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J.Health Sci., 49(3), 239-242, 2003
Negative Correlation between Urinary Selenium and Arsenic Levels of the Residents Living in an Arsenic-Contaminated
Area in Bangladesh
Kaori Miyazaki,*, a Kayo Ushijima,b Takefumi Kadono,c Tsukasa Inaoka,d Chiho Watanabe,a
and Ryutaro Ohtsukaa
aDepartment of Human Ecology, School of International Health, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, bDepartment of Public Health, School of Medicine, Fukuoka University, 7-45-1, Nanakuma, Jyonan-ku, Fukuoka 814-0180, Japan, cDepartment of Dermatology, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, and dDepartment of Environmental Sociology, Faculty of Agriculture, Saga University, 1 Honjo-machi, Saga 840-8502, Japan
Toxicological and metabolic interactions of selenium (Se) with arsenic (As) have been reported in many experimental studies. However, for human populations, possible interactions between As and Se and their toxicological significance have not been established. In this study, we have examined the relationship between Se and As in spot urine samples collected from the inhabitants of two rural communities of northeast Bangladesh. The urinary As (UAs) and Se (USe) concentrations were determined by hydride generation atomic absorption spectrometry (HGAAS). Negative correlation between UAs and USe was found in both males and females. Considering the exposure condition in these communities, it is unlikely that the correlation reflected the correlation between the intakes of these elements. This result suggests that As exposure from drinking water or food may change Se metabolism in humans. Possible toxicological significance of the interaction is discussed.
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