| |
Software Requirements
Microsoft Internet Explorer 5.01 or higher and Netscape Navigator 4.75 or higher are recommended. |
|
 |
J.Health Sci., 49(3), 217-220, 2003
Oxidative DNA Damage is Induced by Chronic Cigarette Smoking, but Repaired by Abstention
Teruo Inoue,*, a Masatoshi Hayashi,b Kan Takayanagi,a and Shigenori Morookaa
aDepartment of Cardiology and bDepartment of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine, 2-1-50, Minamikoshigaya, Koshigaya City, Saitama 343-8555, Japan
The association of chronic cigarette smoking and abstention with oxidative DNA damage was studied. The serum level of an oxidative DNA damage marker, 8-hydroxy-2'-deoxyguanosine (8-OHdG), was measured in 20 healthy male smokers and 8 healthy male non-smokers. The 8-OHdG level was significantly higher in the smokers than in the non-smokers (0.22 ± 0.05 vs. 0.07 ± 0.02 ng/ml, p < 0.001). Ten of 20 smokers abstained from smoking for 4 weeks. Their 8-OHdG levels were significantly reduced by the smoking abstention (0.27 ± 0.05 to 0.14 ± 0.02 ng/ml, p < 0.001). The remaining 10 not only abstained from smoking, but also received 2 g/day of oral vitamin C. Their 8-OHdG levels were also significantly reduced (0.27 ± 0.05 to 0.13 ± 0.02 ng/ml, p < 0.001). However, there was no significant difference in the serial changes in 8-OHdG level between the smoking abstention group and the smoking abstention with vitamin C supplementation group. These results suggest that chronic cigarette smoking enhanced oxidative DNA damage, but the damage was repaired by smoking abstention, and that vitamin C supplementation might not enhance the repair. In light of the DNA damage, smoking abstention should be encouraged.
|
|
