| |
Software Requirements
Microsoft Internet Explorer 5.01 or higher and Netscape Navigator 4.75 or higher are recommended. |
|
 |
J.Health Sci., 49(2), 166-169, 2003
Excretory Profile of 4-Bromo-2,5-dimethoxyphenethylamine (2C-B)
in Rat
Tatsuyuki Kanamori,*, a Kenji
Tsujikawa,a Yoshihito
Ohmae,a Yuko
Iwata,a Hiroyuki
Inoue,a Yoshio
Inouye,b and Tohru Kishia
aFirst Chemistry Section, National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa-shi, Chiba 277-0882, Japan
and bSchool of Pharmaceutical Science, Toho University, 2-2-1 Miyama, Funabashi-shi, Chiba 274-8510, Japan
The urinary and faecal metabolic profiles of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rat were
investigated. Male Wistar rats were administrated 10 mg/kg of 2C-B hydrochloride orally, and the urine and
faeces were collected 0-24 and 24-48 hr after administration. The samples were processed by liquid-liquid
extraction, and the extracts analyzed by GC/MS, after derivatization. The major metabolite excreted into the
urine was 5-O-desmethyl-N-acetyl-2C-B, comprising 13.2% of the administrated dose. Other metabolites
detected in the urinary extracts were
2-O-desmethyl-N-acetyl-2C-B (5.8%),
2-O-desmethyl-2C-B (3.5%), carboxylic acid compound (1.9%),
5-O-desmethyl-2C-B (1.2%) and an alcoholic compound (0.8%). Only 0.2% of the
administrated 2C-B was excreted into the urine in its original form. On the other hand, only
5-O-desmethyl-N-acetyl-2C-B and
2-O-desmethyl-N-acetyl-2C-B were detected in the faecal extracts. The major fraction of the
urinary metabolites that contained a hydroxy group were recovered as conjugates.
|
|
