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J.Health Sci., 49(1), 28-33, 2003
Caenorhabditis elegans Responses to Specific
Steroid Hormones
Nobuaki Tominaga,*, a Kazuhiro
Ura,b Masato
Kawakami,a Tomoaki
Kawaguchi,a Shinya
Kohra,c Yoshinori
Mitsui,d Taisen
Iguchi,b, e and Koji
Arizonob, d
aDepartment of Chemical and Biochemical Engineering, Ariake National College of Technology, 150 Higashi-hagio-machi, Omuta
836-8585, Japan, bCREST, JST, Japan Science and Technology Corporation, 4-1-8 Honmachi, Kawaguchi, Saitama 332-0012,
Japan, cFaculty of Environmental Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan,
dFaculty of Environmental and Symbiotic Sciences, Kumamoto Prefectural University, 3-1-100 Tsukide, Kumamoto 862-8502, Japan, and
eDepartment of Bio-environmental Research, Center for Interactive Bioscience, National Institute for Basic Biology, 38 Nishigonaka
Myodaiji, Okazaki, Aichi 444-8585, Japan
In this paper, Caenorhabditis elegans (C. elegans) is proposed as a model organism for studying chemical effects over multiple generations. We investigated whether C. elegans responds to vertebrate steroid hormones. We found that estrogenic steroids, especially estradiol (E2), have a cholesterol-like potency in supporting the reproduction of C. elegans. In contrast, testosterone (TS) and diethylstilbestrol (DES) did not display this potency. On the other hand, E2, TS and DES supressed the fecundity rate of C. elegans, when culture carried out with cholesterol. Moreover effect of TS accumulated over generation, in contrast to the other chemicals tested. These data suggested that with convenient biomarkers such as fecundity, C. elegans might be an effective model organism for studying chemical actions, including the disruption of reproduction.
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