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J.Health Sci., 48(6), 583-586, 2002
Aquatic Acute Toxicity Testing Using the Nematode Caenorhabditis elegans
Kazuhiro Ura,a, c Toshinori Kai,a Sachiko Sakata,a, c Taisen Iguchi,b, c and Koji Arizono*, a, c
aFaculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, 3-1-100 Tsukide, Kumamoto 862-8502, Japan, bCenter for Integrative Bioscience, Okazaki National Research Institutes, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan, and cCREST, Japan Science and Technology Corporation, 4-1-8 Honmachi, Kawaguchi, Saitama 332-0012, Japan
To evaluate the toxicity of environmental chemicals to invertebrates, a static bioassay was developed in the laboratory using the Caenorhabditis elegans (C. elegans). First, reproducibility of this aquatic acute toxicity test system was confirmed. In order to estimate chemical toxicities in C. elegans, worms were subsequently exposed to eleven different xenobiotics. Mortality after 24hr was adopted as the endpoint of toxicity. We found that benzo[a]pyrene, nonylphenol, benzophenone, bisphenol A and cadmium chloride affected viability of C. elegans. These data suggest that C. elegans is a suitable toxicity test organism for environmental xenobiotic chemicals, and that lethality can be used as a testing endpoint.
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