| |
Software Requirements
Microsoft Internet Explorer 5.01 or higher and Netscape Navigator 4.75 or higher are recommended. |
|
 |
J.Health Sci., 48(6), 579-582, 2002
Bisphenol-A Administration during Pregnancy Results in Fetal Exposure in Mice and Monkeys
Kaoru Uchida,a, b, c Atsuko Suzuki,a, d Yoshio Kobayashi,e David Lee Buchanan,a, c Tomomi Sato,d Hajime Watanabe,a, c Yoshinao Katsu,a, c Juri Suzuki,f Kazuo Asaoka,f Chisato Mori,c, g Koji Arizono,c, h and Taisen Iguchi*, a, b, c, d
aCenter for Integrative Bioscience, Okazaki National Research Institutes, Higashiyama 5-1, Myodaiji, Okazaki 444-8585, Japan, bDepartment of Molecular Biomechanics, The Graduate University for Advanced Studies, Higashiyama 5-1, Myodaiji, Okazaki 444-8585, Japan, cCREST, Japan Science and Technology Corporation, 4-1-8 Honmachi, Kawaguchi 332-0012, Japan, dGraduate School of Integrated Science, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama 236-0027, Japan, eTechnical Laboratory, Analysis Center Corporation, 1-12-2 Higashimukoujima, Sumida-ku, Tokyo 131-0032, Japan, fPrimate Research Institute, Kyoto University, Inuyama, Aichi 484-8506, Japan, gDepartment of Anatomy and Cell Biology, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan, and hFaculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Tsukide 3-1-100, Kumamoto 862-8502, Japan
Placental transfer of bisphenol-A (BPA) was studied in mice and Japanese monkeys (Macaca fuscata). BPA was found in maternal and fetal sera, liver, brain, uteri, testes and placenta as early as 30min after a single subcutaneous (s.c.) injection to 17days of pregnancy in mice. BPA was also found in fetal liver, kidney, and brain of Japanese monkeys 1hr after a single s.c. injection to 150days of pregnancy. These results clearly indicate that the maternal placental barrier can not protect the fetus from the consequences of BPA exposure in these species.
|
|
