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J.Health Sci., 48(6), 527-533, 2002
Testicular Toxicity of Mono-n-Butyl Phthalate and Related Phthalates on Bound Iron in Rat Red Blood Cells
Nobuo Watanabe, Makiko Shimizu, Yoshiaki Matsumoto, and Masamichi Fukuoka*
Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University, Higashi-Tamagawagakuen 3-3165, Machida-city, Tokyo 194-8543, Japan
It was previously reported that free iron was released from rat red blood cells in both an in vitro study with a metabolite, mono-n-butylphthalate (MBP), of di-n-butylphthalate (DBP) and an in vivo study with oral DBP, inducing rat testicular atrophy in hypoxic conditions due to MBP-induced hemoglobin deprivation. This study investigated whether mono-n-alkylphthalates (alkyl-carbon C4-C6 ; MAP), which result in rat testicular damage, induce iron release from hemoglobin by incubation with rat red blood cells. Iron release was observed with C3-C6 MAP incubation at lower doses and with C1 and C2 MAP incubation at higher doses, but not with C7, C8, and C4(6) MAP.
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