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J.Health Sci., 48(5), 451-454, 2002
Application of Supermex System to Screen Behavioral Traits Produced by Tributyltin in the Rat
Masami Ishido,*, a Yoshinori Masuo,b, c Syuichi Oka,b Manabu Kunimoto,d and Masatoshi Moritaa
aEndocrine Disruptors and Dioxin Research Projects, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba 305-8506, Japan, bInternational Patent Organism Depositary, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba 305-8566, Japan, cNEDO, 3-1-1 Higashiikebukuro, Toshima-ku, Tokyo 170-6028, Japan, and dDepartment of Public Health, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan
It has been unknown whether or not endocrine disruptors exert their effects on neuronal functions, particularly leading to behavioral alterations. To address this hypothesis, we applied the Supermex system that detects the radiated body heat of an animal, representing the spontaneous motor activity of it. Intracisteral administration of tributyltin, an endocrine disruptor, into 5-day-old Wistar rats caused hyperactivity at 4-5 weeks of age. It was about 1.4 fold more hyperactive than vehicle-treated rats in the dark phase, but not in the light phase. Thus, it might be possible to apply the Supermex system to screen the behavioral deficits produced by other endocrine disruptors.
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