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J.Health Sci., 48(4), 346-349, 2002
Cytochrome P450 Expression in Rat Ocular Tissues and Its Induction by Phenobarbital
Hiroyuki Tanaka, Ikuko Hirayama, Makoto Takehana, Shizuko Kobayashi, and Hiro-omi Tamura*
Kyoritsu College of Pharmacy, 1-5-30 Shibakoen, Minatoku, Tokyo 105-8512, Japan
Composition and inducibility of cytochrome P450 (CYP) in ocular tissues were investigated using reverse transcription-polymerase chain reaction (RT-PCR) and immunoblot techniques. Composition of ocular CYPs is more restricted than that of hepatic forms. High levels of CYP2B1/2 and reduced levels of CYP2C11 expression were detected in rat ocular tissues. Phenobarbital induced CYP2B1/2 expression in the lens but not in the rest of the eye, whereas CYP2C11 induction was observed in both regions. In addition, CYP2B1/2 proteins were found to be prominent in the retina. Our data indicate eye-specific regulation of CYP expression.
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