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J.Health Sci., 48(4), 317-324, 2002
Maternal Exposure to Diesel Exhaust Decreases Expression of Steroidogenic Factor-1 and Mullerian Inhibiting Substance in the Murine Fetus
Miki Yoshida,a Seiichi Yoshida,a, c Isamu Sugawara,b, c and Ken Takeda*, a, c
aDepartment of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 12 Ichigaya, Funagawara-machi, Shinjuku-ku, Tokyo 162-0826, Japan, bDepartment of Molecular Pathology, The Research Institute of Tuberculosis, 3-1-24 Matsuyama, Kiyose-shi, Tokyo 204-8533, Japan, and cCREST, JST (Japan Science and Technology Corporation), 4-1-8 Hon-cho, Kawaguchi-shi, Saitama 332-0012, Japan
We investigated the effect of exposure of pregnant mice to diesel exhaust on male gonad development at the level of mRNA expression. Expression of mRNAs for steroidogenic factor-1 (Ad4BP/SF-1) and Mullerian inhibitory substance (MIS), which are essential for male gonadal differentiation, decreased significantly in male fetuses when maternal mice were exposed to diesel exhaust at levels of 0.1 mg and 3.0 mg diesel exhaust particles (DEP)/m3 for 8 hr per day between days 2 and 13 post coitum. Expression levels of mRNAs for steroidogenic cytochrome P450 genes regulated by Ad4BP/SF-1, especially 3beta -hydroxysteroid dehydrogenase (3beta-HSD) and aromatase, were also decreased by exposure to diesel exhaust. There were no significant differences in levels of estrogen receptor (ER) or androgen receptor (AR) mRNAs between control and exposed mice. The data indicate that exposure of pregnant mice to diesel exhaust affects the expression of genes essential in the early stages of embryonic development.
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