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J.Health Sci., 48(3), 273-276, 2002
Antibacterial Activity of Extracts Prepared from Tropical and Subtropical Plants on Methicillin-Resistant Staphylococcus aureus
Tomoko Nitta,a Takashi Arai,a Hiromu Takamatsu,a Yuka Inatomi,a Hiroko Murata,a Munekazu Iinuma,b Toshiyuki Tanaka,b Tetsuro Ito,c Fujio Asai,c Iriya Ibrahim,c Tsutomu Nakanishi,a
and Kazuhito Watabe*, a
aFaculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573-0101, Japan, bGifu Prefectural Institute of Health and Environmental Sciences, Kakamigahara 504-0838, Japan, and cDepartment of Pharmacognosy, Gifu Pharmaceutical University, Gifu, Gifu 502-0003, Japan
The antibacterial activity of the extracts prepared from 181 species (75 families) of tropical and subtropical plants was screened against various types of pathogenic bacteria. Among the 505 extracts tested, 53 of them inhibited the growth of methicillin-resistant Staphylococcus aureus (MRSA). The active extracts obtained from barks of Shorea hemsleyana and roots of Cyphostemma bainessi were separated to their components, some of which greatly reduced the viable cell number of MRSA. These active compounds were all identified as stilbene derivatives. Hemsleyanol D, one of the stilbene tetramer isolated from S. hemsleyana, was the most effective compound and had MIC of 2 mu g/ml.
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