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J.Health Sci., 47(2), 97-105, 2002
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Liver Proteins that are Sensitive to a Dioxin-Like Toxic Compound, Coplanar Polychlorinated Biphenyl, 3,3',4,4',5-Pentachlorobiphenyl
Yuji Ishii*, a and Kazuta Ogurib
aDepartment of Environmental Medicine, Institute of Community Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan and bGraduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
This review deals with the reducing ability of a dioxin-like toxic compound, coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl (PCB126) in protein levels of rat liver aldolase B, carbonic anhydrase III, class I alcohol dehydrogenase (ADH), glucose regulated protein 78 (GRP78), GRP94, calreticulin, and calnexin as well as the inducing ability in hepatic cytosolic 54 K protein (tentative selenium binding protein/acetaminophen binding protein homologue), heat shock protein 70 (HSP70) and HSP90. These data could provide new aspects of dioxin's toxicity via marked changes in the levels of proteins with important functions.
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