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J.Health Sci., 48(2), 204-207, 2002
Effect of Carbon Tetrachloride on 3'-AMP-Forming Enzyme Activity in Rat Liver
Hiroyuki Fujimori* and Hidemitsu Pan-Hou
Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan
The effect of carbon tetrachloride (CCl4) on adenosine 3'-monophosphate (3'-AMP) content and 3'-AMP-forming enzyme activity in rat liver was examined. The levels of 3'-AMP and the total amounts of adenosine 5'-triphosphate, adenosine 5'-diphosphate and adenosine 5'-monophosphate were decreased by treatment with CCl4. The 3'-AMP-forming enzyme activity in CCl4-treated rat liver homogenate was ca. 4-fold higher than that of control. The enzyme activity in CCl4-treated mitochondria was ca. 50% of control values. These results suggest that the increase in the 3'-AMP-forming enzyme activity in the cytosol may be, at least partly, due to the leakage of the enzyme activity from mitochondria in acute hepatitis induced by CCl4.
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