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J.Health Sci., 48(2), 201-203, 2002
Wistar-Imamichi Rats Exhibit a Strong Resistance to Cadmium Toxicity
Hideaki Shimada,a Masaaki Nagano,b Akira Yasutake,b and Yorishige Imamurac, *
aFaculty of Education, Kumamoto University, 2-40-1 Kurokami, Kumamoto 860-8555, Japan, bNational Institute for Minamata Disease, Minamata, Kumamoto 867-0008, Japan, and cFaculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan
The strain difference in the toxicity of cadmium (Cd) was examined in male rats. All rats of the Wistar-Imamichi (Wistar-IM) strain survived for 7 days after treatment with Cd at a dose of 5.0 mg/kg body weight, whereas 80% of the Wistar strain and 100% of the Sprague-Dawley and Fischer strains died. These results indicate that the Wistar-IM strain has strong resistance to Cd. Furthermore, the metallothionein (MT) contents of the liver, kidney and testis of Wistar-IM rats were compared with those of Fischer rats. The strain difference in the toxicity of Cd in rats did not appear to result from a difference in MT content, although further study is necessary to elucidate the role of MT.
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