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J.Health Sci., 48(1), 89-92, 2002
Influence of Temperature on the Efficacy of 2-Phenoxyethanol as a Preservative for Adsorbed Diphtheria-Purified Pertussis-Tetanus Combined Vaccine
Eiji Komatsu,a Hiroyuki Yamazaki,a Katsuyo Abe,a Shigeharu Iyama,a Mitsuo Oishi,a Takaaki Sato,a Chiharu Yoshino,b Hiroshi Hashimoto,b Mineo Watanabe,c and Masaaki Nagai*, a
aDivision of Bacterial Vaccines and bDivision of Quality Control, Research Center for Biologicals, The Kitasato Institute, 6-111 Arai, Kitamoto, Saitama 364-0026, Japan and cLaboratory of Pertussis, Department of Microbiology and Biologics, Daiichi College of Pharmaceutical Sciences, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan
The efficacy of two antimicrobial preservatives, 2-phenoxyethanol (2-PE) and Thimerosal, was compared in adsorbed diphtheria-purified pertussis-tetanus combined vaccine (DPT vaccine). Thimerosal had strong microbicidal activity against Gram-positive bacteria, Gram-negative bacteria, yeast and fungi at 25°C and 4°C. 2-PE also had microbicidal activity against these microorganisms, only had microbistatic activity against fungi at 4°C. Neither 2-PE nor Thimerosal affected the potency or toxicity of the DPT vaccine. These data suggest that 2-PE has weaker antimicrobial activity than Thimerosal against yeast and fungi in DPT vaccine at low temperatures.
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