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J.Health Sci., 48(1), 73-78, 2002
Mutagenicity Testing of 1,3-Butadiene, 1,4-Pentadiene-3-ol , Isoprene, 2,4-Hexadiene, cis- and trans-Piperlylene
Bathini Madhusree,*, a Sumio Goto,b Tadamichi Ohkubo,c Hailin Tian,d Fukue Ando,e Morio Fukuhara,a Masahiro Tohkin,a and Ikuo Watanabef
aDepartment of Pharmaceutical Sciences, National Institute of Public Health, Shirokanedai 4-6-1, Minato-Ku, Tokyo 108-8638, Japan, bReseacrh Center for Material Cycles and Waste Management, National Institute for Environmental Studies, Onogawa 16-2, Tsukuba-shi, Ibaraki 305-0053, Japan, cDepartment of Food Science and Technology, Tokyo University of Fisheries, Konan 4-5-7, Minato-ku, Tokyo 108-8477, Japan, dDepartment of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater OK, 74078, U.S.A., eChemical Safety Division, Chemical Product Quality Assurance Center, Cannon Inc., 30-2, Shimomaruko 3-chome, Ohta-ku, Tokyo 146-8501, Japan, and fDepartment of Community Environmental Sciences, National Institute of Public Health, Shirokanedai 4-6-1, Minato-Ku, Tokyo 108-8638, Japan
A mutagenicity test was conducted for 1,4-pentadiene-3-ol, 2,4-hexadiene, isoprene, cis- and trans-piperylene in the bacterial mutation assay using Salmonella typhimurium (S. typhimurium) strain TA 100, TA98, TA1535 and Escherichia coli (E. coli) WP2uvrA/pKM101 with and without metabolic activation by S9 mix in the preincubation method. The mutagenicity of 1,3-butadiene was tested by the gas exposure method. Mutagenicity was weakly positive for 1,4-pentadiene-3-ol in TA 100 with S9 mix and was pseudopositive for WP2uvrA/pKM101 without S9 mix. Mutagenicity was very clear for 1,3-butadiene in 10 fold concentrated TA1535 with S9 mix. The 2,4-hexadiene, isoprene, cis-piperlylene and trans-piperlylene were not mutagenic on S. typhimurium TA98, TA100, TA1535 or E. coli WP2uvrA/pKM101 with or without metabolic activation. It can be concluded from these results, that chemicals, containing double bond carbon (C=C) chemical generally tend to show weak mutagenicity in the presence of the metabolic activation system.
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