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J.Health Sci., 47(5), 491-494, 2001
Adsorption Studies of Artesunate: Evaluation of Saline Cathartics as Additive in Management of Artesunate Poisoning
Orish Ebere Orisakwe,*, a Adeola Oluboyo,a Sabinus Ofoefule,b Ejeatuluchukwu Obi,a Ndidi Ilondu,a Onyenmechi Johnson Afonne,a Patrick Agbasi,a
and Danladi Husaini Chiromaa
aToxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, P.M.B. 5001, Anambra State, Nigeria and bDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Nigeria, Nsukka Enugu State, Nigeria
The effect of saline cathartics magnesium sulphate, sodium sulphate, and sodium citrate on adsorptive capacity of activated charcoal (AC) was investigated in vitro. Solutions of artesunate alone and artesunate with 7.5 mg/ml cathartics solution were vortex mixed for 30 sec with different quantities of AC, incubated in water bath shaker for 30 min at 37°C and analysed for free artesunate spectrophotometrically at 328 nm. Addition of the cathartics caused a significant increase (p < 0.05) in the adsorption of artesunate to activated charcoal. The descending order of increased adsorption by the cathartics is magnesium sulphate, sodium citrate and sodium sulphate.
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