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J.Health Sci., 47(5), 473-477, 2001
Inhibitory Effect of Plant Extracts on Production of Verotoxin by Enterohemorrhagic Escherichia coli O157 : H7
Yoshikazu Sakagami,*, a Hiroko Murata,b Tsutomu Nakanishi,b Yuka Inatomi,b Kazuhito Watabe,b Munekazu Iinuma,c Toshiyuki Tanaka,c Jin Murata,d and Frank A. Lange
aOsaka Prefectural Institute of Public Health, 1-3-69 Nakamichi, Higashinari-ku, Osaka 537-0025, Japan, bFaculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan, cGifu Prefectural Institute of Health and Environmental Sciences, Nakafudougaoka, Kakamigahara, Gifu 504-0838, Japan, dBotanical Gardens, Graduate School of Science, the University of Tokyo, 3-7-1 Hakusan, Bunkyo-ku, Tokyo 112-0001, Japan, and eDepartment of Biology, Southern Oregon University, Ashland, Oregon, 97520-5071, U.S.A.
The inhibitory effect of several plant extracts on the production of verotoxin by enterohemorrhagic Escherichia coli O157 : H7 (EHEC) was investigated. The extracts from four plant species, Limonium californicum (Boiss.) A. Heller, Cupressus lustianica Miller, Salvia urica Epling and Jusiaea peruviana L., were effective on the inhibition for verotoxin production (31.3-125 mu g/ml). The inhibition against verotoxin production was observed at a concentration lower than the minimal inhibitory concentration (MIC) of each extract of test plants (1000 mu g/ml), indicating that these plant extracts would preferentially prevent the production of verotoxin rather than bactericidal effect on EHEC. These findings suggest that the administration of any appropriate plant extract might prevent the production of verotoxin on EHEC in the human intestines.
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