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J.Health Sci., 47(5), 439-445, 2001
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Induction of Oxidative Stress and Dysfunction of Nitric Oxide-Dependent Vascular Tone Caused by Quinones Contained in Diesel Exhaust Particles
Yoshito Kumagai* and Nobuhiro Shimojo
Department of Environmental Medicine, Institute of Community Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan
This article reviews studies of overproduction of reactive oxygen species during reductive activation of quinones contained in diesel exhaust particles. The resulting inhibition of nitric oxide synthase activity causing suppression of vasorelaxation by phenanthraquinone, one of the quinone in diesel exhaust particles, is also reviewed.
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