| |
Software Requirements
Microsoft Internet Explorer 5.01 or higher and Netscape Navigator 4.75 or higher are recommended. |
|
 |
J.Health Sci., 47(3), 318-322, 2001
Monoester Formation by Hydrolysis of Dialkyl Phthalate Migrating from Polyvinyl Chloride Products in Human Saliva
Tatsuhiro Niino,*, a Tohru Ishibashi,a Takeshi Itho,a Senzo Sakai,a Hazimu Ishiwata,b Takashi Yamada,c and Sukeo Onoderad
aTokyo Kenbikyo-in Foundation, Center of Food & Environmental Sciences, 44-1 Nihonbashi Hakozaki-cho, Chuo-ku, Tokyo 103-0015, Japan, bNational Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan, cJapan Food Additives Association, Nihonbashi-San-Ei-Bldg., 3F 1-3-9 Nihonbashi-Horidome-cho Chuo-ku, Tokyo 103-0012, Japan, and dFaculty of Pharmaceutical Sciences, Tokyo University of Science, 12 Ichigaya-Funagawara-machi, Shinjuku-ku, Tokyo 162-0826, Japan
The migration dialkyl phthalate was tested in volunteers who chewed polyvinyl chloride (PVC) toy products under controlled conditions. The PVC toy samples consisted of ball A containing 100 and 185 mg/g di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP) respectively, and ball B, containing 256 mg/g diisononyl phthalate (DINP). The migration of dialkyl phthalate into simulated saliva was also tested in vitro by shaking toy samples. The migration rates of DBP, DEHP and DINP from balls A and B were 11.7, 44.4 and 78.0 mu g/10 cm2/hr, respectively, in vivo, and 339, 315 and 535 mu g/10 cm2/hr, respectively, in vitro. The presence of mono-n-butyl phthalate (MBP) and mono-2-ethylhexyl phthalate (MEHP) in saliva collected after chewing ball A was confirmed by GCMS-SIM. Human saliva which collected from volunteers incubated with DBP and DEHP at 37°C over 60 min, hydrolyzed these compounds to their monoesters.
|
|
