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J.Health Sci., 47(2), 175-183, 2001
Changes in Middle Latency Auditory-Evoked Potentials of the Rat Exposed to Styrene
Yu-ping Wang,a Takeshi Saito,*, a Toshiyuki Hosokawa,b Masaaki Kurasaki,c and Kazuo Saitoa
aLaboratory of Environmental Biology, Hokkaido University School of Medicine, Sapporo 060-8638, Japan, bCenter for Research and Development in Higher Education, Hokkaido University, Sapporo 060-0817, Japan, and cDepartment of Environmental Medicine and Informatics, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060-0810, Japan
Effects of styrene exposure on middle latency auditory-evoked potentials (MAEPs), which reflect the central auditory function, were investigated. As significant delay in latencies of No, Po, Na, and Pa components and increases in the peak to peak intervals of MAEPs, but not amplitudes, were observed in a dose-dependent manner. The present and our previous studies demonstrate that electrophysiological alterations occur before neuronal cell damage induced by styrene exposure. The present results suggested that styrene has a marked effect on the processing of auditory information related to MAEPs.
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