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J.Health Sci., 47(1), 72-74, 2001
Detection of DNA-Reactive Metabolites in Human Serum after 1,4-Dichlorobenzene Inhalation: Role of Human Biomonitoring
Hailin Tian,a Bathini Madhusree,a Morio Fukuhara,a Hiroshi Miyazawa,*, a Sumio Goto,b and Toshiaki Yoshidac
aDepartment of Pharmaceutical Sciences, bDepartment of Community Environmental Sciences, National Institute of Public Health, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8638, Japan, and cDivision of Industrial Health, Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome, Higashinari-ku, Osaka 537-0025, Japan
Three healthy volunteers were exposed to 1,4-dichlorobenzene (p-DCB) vapor (2.4-2.8 ppm) for 1 hr, peripheral blood was taken before and after exposure. Serum was collected and incubated with calf thymus DNA to examine whether there are any DNA-binding metabolites persisting in human serum. Among the 3 subjects we detected 4, 2, and 0 DNA adducts respectively, no differences were found in adduct profiles before or after p-DCB inhalation. The result reflects that qualities and quantities of DNA-reactive metabolites in human sera are different, depending upon individual exposure to environmental carcinogens and their metabolism ability. There were no additional DNA-reactive metabolites found after inhalation exposure to p-DCB.
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