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J.Health Sci., 46(6), 503-508, 2000
Subacute Vanadium Toxicity in Rats
Atsuko Adachi,* Kaoru Asai, Yukari Koyama, Yumiko Matsumoto, and Toshio Okano
Department of Hygienic Sciences, Kobe Pharmaceutical University, 4-chome, Motoyamakita-machi Higashinada-ku, Kobe, 658-8558, Japan
Subacute vanadium toxicity was investigated in rats. Female Wistar strain rats, weighing 180 g (approximately 6 weeks old), were divided into three groups of seven each. They were fed a base diet with addition of various concentrations of vanadium (0, 50 or 100 ppm) for 10 weeks. The amounts of vanadium found in kidney and liver increased in response to vanadium exposure. A significant increase in metallothionein (MT) was observed in kidney of both the 100 ppm and 50 ppm vanadium-fed groups. Significant decreases in hemoglobin, hematocrit and leukocyte counts were also observed in the former, as well as decreased lymphocyte counts, B cells and immunoglobulin G and M levels.
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