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J.Health Sci., 46(5), 363-369, 2000
Supplemental Intake of Isoflavones and Zinc-Containing Mineral Mixture Enhances Bone Components in the Femoral Tissue of Rats with Increasing Age
Zhong Jie Ma,a Aki Igarashi,a Masaru Inagaki,b Fumio Mitsugi,c and Masayoshi Yamaguchi*, a
aLaboratory of Endocrinology and Molecular Metabolism,
Graduate School of Nutritional Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan,
bInstitute for Consumer Healthcare, Yamanouchi Pharmaceutical Co., Ltd.,
Itabashi-ku, Tokyo 174-8612, Japan, and
cMedical Information Group, Sanwell Co., Ltd., Taito-ku, Tokyo 111-0034, Japan
The effect of the supplemental intake of isoflavone and a zinc-containing mineral mixture on bone components in the femoral tissue of rats was investigated.
Rats (5 weeks old) were orally administered either vehicle, isoflavone glycoside (5 mg/100 g body weight), aglycone isofavone (5 mg/100 g, including 3.772 mg daidzein,
0.395 mg genistein, and 0.833 mg glycitein), zinc-containing mineral mixture (0.833 mg zinc, 50 mg calcium, 25 mg magnesium, and 0.208 mu g vitamin
D3 per 100 g body weight, respectively),
or both aglycone isoflavone (5 mg/100 g) and zinc-containing mineral mixture for 7 d. Administrations resulted in a significant increase in femoral dry weight, calcium content, alkaline phosphatase activity, and DNA content in the femoral-diaphyseal and metaphyseal tissues. Femoral zinc content was significantly increased by the administration of zinc-containing mineral mixtures with or without aglycone isoflavone. The effect of aglycone isoflavone in elevating bone components was significantly enhanced in combination with the zinc-containing mineral mixture. Moreover, the oral administration of both aglycone isoflavones and zinc-containing mineral mixture to aged rats (50 weeks old) for 21 d resulted in a significant increase in femoral dry weight, zinc content, and bone components. This study demonstrates that supplemental intake of both aglycone isoflavone and a zinc-containing mineral mixture has an anabolic effect on bone components in aged rats, suggesting the role of nutrients in the prevention of osteoporosis with increasing age.
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