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J.Health Sci., 46(3), 214-218, 2000
The Mutagenic Activity of the Crude Extract Obtained from Silicon Dioxide and Titanium Dioxide with Pyrene and Sodium Chloride under Xenon Lamp Irradiation
Hidetoshi Sugiyama,*,a Tetsushi Watanabe,b and Teruhisa Hirayamab
aKanagawa Environmental Research Center, 842 Nakahara-shimojuku, Hiratsuka-shi, Kanagawa 254 -0072, Japan and bKyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607 -8414, Japan
The mutagenic activity of the crude extract obtained from the reaction mixture of pyrene and sodium chloride in the presence of 2 metallic oxides［silicon dioxide : silicic anhydride form (SiO2) and titanium dioxide : anatase form (TiO2)］under xenon lamp irradiation was examined using Salmonella typhimurium tester strains (TA98 and TA100), and was compared with the mutagenic activity of 1-chloropyrene (1-CP), dichloropyrenes (DCP), 1-nitropyrene (1-NP) and dinitropyrenes (DNP) in the crude extract. In the presence of SiO2, the mutagenicity of 1-NP in the crude extract, and that of the crude extract increased with the progress of the irradiation time. Moreover, the crude extract and 1-NP levels of mutagenicity were considerably similar in each exposure time. Accordingly, it was presumed that the increase of the mutagenic activity of the crude extract was caused by the increase of the yields of 1-NP in the crude extract. In the presence of TiO2, the mutagenicity of 1-NP in the crude extract decreased for the extended irradiation time, but the mutagenicity of the crude extract increased in reverse. It was presumed that the increase of the mutagenic activity of the crude extract was due to increasing the yields of other strong mutagens other than 1-CP, DCP or 1-NP.
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