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J.Health Sci., 46(3), 209-213, 2000
Influence of Histidine on Zinc Transport into Rat Brain
Atsushi Takeda,* Mai Suzuki, Shoji Okada, and Naoto Oku
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 -1 Yada, Shizuoka 422 -8526, Japan
The brain of rats injected intravenously with 65Zn-His or 65ZnCl2 was subjected to autoradiography to study the role of histidine on zinc transport into the brain. One hour after injection, the radioactivity from 65Zn-His was largely concentrated in the choroid plexus in the ventricles. Six days after injection, the radioactivity from 65Zn-His was relatively concentrated in the hippocampal CA3 and dentate gyrus and the amygdala. The relative distribution of 65Zn-His in the brain was similar to that of 65ZnCl2 group at both 1 h and 6 days, suggesting that histidine may participate in zinc uptake in the brain. On the other hand, the clearance of the 65Zn-His group from the blood was higher than that of the 65ZnCl2 group. Brain uptake of the former was lower than that of the latter both 1 h and 6 days after injection. These results suggest that zinc uptake in the brain is influenced by histidine levels in the bloodstream.
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