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J.Health Sci., 46(1), 29-34, 2000
Screening of the Desmutagenic Capacity of an Extract from Crude Drug by Spore Rec-Assay
Seiichi Ueno,* Kazuko Aoki, and Mutsuo Ishizaki
Ibaraki Prefectural Hygienic Laboratory, 993-2, Kasahara-cho, Mito 310-0852, Japan
We investigated the desmutagenic action of extracts from Smilax rhizome, Mulberry bark and Berchemia racemosa on Trp-P-1 and Trp-P-2 by means of spore rec-assay. The results obtained are as follows: (1) 50% ethanol and ethanol extracts from each crude drug showed desmutagenic action on Trp-P-1 and Trp-P-2. (2) Most of the desmutagenic activity in 50% ethanol extract from each crude drug was due to an ethyl acetate soluble fraction. (3) The interaction between the ethyl acetate soluble fraction from each crude drug and Trp-P-1 was much stronger in Mulberry bark and Berchemia racemosa than in Smilax rhizome.
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