| |
Software Requirements
Microsoft Internet Explorer 5.01 or higher and Netscape Navigator 4.75 or higher are recommended. |
|
J.Health Sci., 45(6), 333-343, 1999
- Review -
Carcinogenicity of Inorganic Arsenics and Its Mechanistic Concepts[in Japanese]
Kenzo Yamanaka*,a and Shoji Okadab
aNihon University College of Pharmacy, 7-7-1 Narashinodai, Funabashi 274-8555, Japan and bUniversity of Shizuoka School of Pharmaceutical Sciences, 52-1 Yada, Shizuoka 421-0826, Japan
Inorganic arsenics such as arsenite and arsenate have been concluded to have human carcinogenicity for skin and lung by epidemiological studies, although animal experimental evidence for their carcinogenicity is inadequate for evaluation.
Moreover, genotoxic action of arsenics is obscure ; inorganic arsenics do not induce point mutation but induce chromosomal aberrations, transformation, and other genetic damage.
Here we review and evaluate the published information on arsenic genotoxicity and carcinogenicity in humans and animals, including current mechanistic concepts.
|
|
