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J.Health Sci., 45(6), 318-323, 1999
Passage of Bisphenol A into the Fetus of the Pregnant Rat
Hidekazu Miyakoda, Masako Tabata, Sukeo Onodera, and Ken Takeda*
Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya-Funagawara-machi, Shinjuku-ku, Tokyo 162-0826, Japan
We examined whether orally administered bisphenol A transfers from the maternal rat to the fetus.
After oral dose of 10 mg/kg bisphenol A, it immediately appeared in maternal blood, and transferred into the fetuses.
The concentration of bisphenol A in both maternal blood plasma and fetuses peaked within 1 h after administration.
The values were approximately 34 ppb and 11 ppb, respectively.
At 3 h, the concentration of bisphenol A in maternal blood plasma had decreased to approximately 10% of the peak value.
The 3-h decrease in fetuses was only about 40% of the peak, and by 24 h, the fetal concentration had increased again to the nearly 70% of the peak value.
The results suggest that bisphenol A might easily pass through the placental barrier, unlike sex hormones such as estrogen.
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