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J.Health Sci., 45(6), 303-308, 1999
Highly Specific and Convenient Color Reaction for Methylenedioxymethamphetamine and Related Drugs Using Chromotropic Acid. Application as a Drug Screening Test
Hideyuki Yamada,a Sachiko Ikeda-Wada,b and Kazuta Oguri*,a
aGraduate School of Pharmaceutical Sciences, Kyushu University 62, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan and bKyushu District Narcotic Control Office, 2-10-7 Hakataeki-higashi, Hakata-ku, Fukuoka 812-0013, Japan.
The color reaction of various drugs with chromotropic acid and sulfuric acid was examined.
Methylenedioxymethamphetamine (MDMA) exhibited a red-violet color on treatment of an aqueous solution with sulfuric acid and chromotropic acid.
The specificity of the reaction was examined using 65 drugs.
The results showed that while related drugs with a methylenedioxyphenyl moiety, such as methylenedioxy-amphetamine and -N-ethylamphetamine, were all positive, 51 drugs including amphetamine, methamphetamine, opiates, cocaine, and phencyclidine were negative.
The drugs exhibiting a positive reaction include tetrahydrocannabinol and related drugs, sulfur-containing drugs such as phenothiazine tranquilizers, and diphenhydramine.
These results indicate that the present method is highly specific for MDMA and related drugs although its specificity is not absolute.
The detection of MDMA in urine was investigated, and found to be possible using this method.
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