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J.Health Sci.,45(5), 271-275,1999
Comparative Studies of Dialyzability of Levofloxacin and Amlodipine Using in Vitro Dialysis System with Three Different Types of Dialyzers
Mayumi Mochizuki, Rieko Yuda, Fumi Amano, Yuki Nakajima, Shin-ichi Yamagata, Shigeto Oda, Shinji Yamane, Masayuki Ishii, and Shiro Ueda
Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba-shi, Chiba 263-8522, Japan and Division of Blood Purification, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8677, Japan
In the pharmacotherapy of patients receiving hemodialysis, the possible exclusion of an administered drug by hemodialysis should be recognized. The present study was undertaken to predict dialyzability of a drug during hemodialysis using an in vitro dialysis system with three different dialyzers made from high performance membrane. Levofloxacin having relatively low binding-affinity to plasma protein was removed ideally during in vitro dialysis. Amlodipine was also eliminated from the blood, although it is generally believed that such drugs with high binding affinity to plasma protein are removed less efficiently. Examination of the adsorption rate and clearance of the drug revealed that disappearance of amlodipine was due to its adsorption to dialysis membrane and its circuit. Thus, drugs with high protein binding-affinity may possibly be removed by dialyzers with high performance membrane.
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