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J.Health Sci.,45(5), 262-265,1999
Effect of Fenthion on the Level of Vitellogenin in Goldfish, Carassius auratus
Shigeyuki Kitamura, Mayumi Yoshida, Kazumi Sugihara, Shigeru Ohta, and Akihiko Hara
Institute of Pharmaceutical Science, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan and ｂFaculty of Fisheries, Hokkaido University, 3-1-1 Minato, Hakodate, Hokkaido 041-0821, Japan
The estrogenic effect of fenthion, an insecticide, in goldfish (Carassius auratus) was examined in terms of the induction of vitellogenin, a biomarker of estrogens in fish. When male goldfish were kept in water containing diethylstilbestrol (0.1 mg/l) or nonylphenol (0.5 mg/l) for 5 days, a significant level of vitellogenin in the blood was observed. However, vitellogenin was not detected in the blood of male goldfish kept in water containing fenthion (3 mg/l) for 5 days. When female goldfish were kept in water containing fenthion for 5 days, the levels of vitellogenin in the blood were not enhanced. Furthermore, fenthion sulfoxide and fenthion sulfone, the oxidized products of fenthion, did not induce vitellogenin in male goldfish. These results suggest that fenthion and its oxidized products do not produce estrogenic activity in goldfish.
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